TA326461 ABCC9 / SUR2A (1505- 1546, Cytopl. Dom.) antibody

Mouse Monoclonal Anti-SUR2A Antibody

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Search for all "ABCC9 / SUR2A"

0.1 mg / €410.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Mouse, Rat ABCC9 / SUR2A S319A-14

TA326461

Product Description for ABCC9 / SUR2A

Mouse anti Mouse, Rat ABCC9 / SUR2A S319A-14.
Properties: (1505- 1546, Cytopl. Dom.)
Presentation: Purified
Product is tested for Paraffin Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for ABCC9 / SUR2A

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms ATP-binding cassette transporter sub-family C member 9, Sulfonylurea receptor 2A, isoform SUR2A
Presentation Purified
Reactivity Ms, Rt
Applications ICC/IF, P, WB
Clonality Monoclonal
Clone S319A-14
Host Mouse
Isotype IgG2a
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P70170
Immunogen:
Fusion protein, amino acids 1505-1546 (cytoplasmic, C-terminus) of Mouse ABCC9 / SUR2A
AA Sequence:
SSIVDAGLVLVFSEGILVECDTGPNLLQH KNGLFSTLVMTNK
GeneID:
20928
Property 1505- 1546, Cytopl. Dom.
Isotype control AM03096PU-N
Application Western Blot: 1 μg/ml of this antibody was sufficient for detection of ABCC9 / SUR2A in 20μg of Mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-Mouse IgG-HRP as the secondary antibody.
Immunocytochemistry.
Immunohistochemistry: Free floating sections, fixed in formaldehyde.
Background Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inwardrectifier potassium ion channels Kir6.x (6.1 and 6.2) (2).  The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (1).
Concentration 1.0 mg/ml
General Readings
  1. Nichols CG. KATP channels as molecular sensors of cellular metabolism. Nature. 2006 Mar 23;440(7083):470-6. PubMed PMID: 16554807.
  2. Campbell JD, Sansom MS, Ashcroft FM. Potassium channel regulation. EMBO Rep. 2003 Nov;4(11):1038-42. PubMed PMID: 14593442. (Free PMC Article available, 3 images available)
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Protein G Chromatography
Buffer System:
PBS pH 7.4, 50% Glycerol
Preservatives:
0.09% Sodium Azide
State:
Liquid purified IgG fraction
Purified
Specificity
Specificity:
This antibody detects ABCC9  isoform SUR2A (aa1505-1546); ~ 120 kDa.
Does not cross-react with isoform SUR2B.
Species:
Mouse, Rat.

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