AP08038PU-N ABL1 / ABL2 pTyr393/439 antibody

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0.1 ml / €320.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse ABL1 / ABL2

AP08038PU-N

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Product Description for ABL1 / ABL2

Rabbit anti Human, Mouse ABL1 / ABL2.
Properties: pTyr393/439
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for ABL1 / ABL2

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms ABL1, ABL2, Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody, Bcr/c abl oncogene protein antibody, JTK7, Transformation gene oncogene ABL antibody, bcr/abl, c-ABL, p150
Presentation Aff - Purified
Reactivity Hu, Ms
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P00519
Immunogen:
Synthetic phosphopeptide derived from human ABL1/2 around the phosphorylation site of Tyrosine 393/439 (D-T-Yp-T-A).
GeneID:
25
Property pTyr393/439
Application Immunofluorescence: 1/100 - 1/200.
Immunohistochemistry on Paraffin-Embedded Sections: 1/50 - 1/100.
Western Blot: 1/500 - 1/1000; Incubate membrane with diluted antibody in 5% nonfat milk, 1X TBS, 0,1% Tween-20 at 4°C with gentle shaking, overnight.
Background ABL1, an Abl type protein kinase, is associated with cell differentiation, cell division, cell adhesion and stress response. Kinase activity of nuclear ABL1 is mediated by retinoblastoma protein. Additionally, ABL1 has been shown to bind nuclear DNA, and this binding activity is regulated by CDC2-mediated phosphorylation. ABL1 (-/-) mice are osteoporotic and display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation of B cells in bone marrow. At least two mRNA isoforms have been reported, 6- or 7-kb, with alternatively spliced first exons joined to the common exons 2-11. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation. Further, a very long intron in the ABL1 gene is a target for translocations. Translocations of ABL1 to the breakpoint cluster region (BCR) on chromosome 22 lead to chronic myeloid leukemia and acute lymphocytic leukemia.
Concentration 1.0 mg/ml
General Readings
  1. Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650.
  2. Danial, N.N. et al. (2000) Oncogene 19, 2523-2531.
  3. Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637.
  4. Pluk, H. et al. (2002) Cell 108, 247-259.
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Affinity Chromatography
Buffer System:
PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State:
Liquid purified IgG fraction
Aff - Purified
Specificity
Specificity:
ABL1/ABL2 antibody detects endogenous levels of ABL1/2 only when phosphorylated at Tyrosine 393/439.
Species:
Human and Mouse.

Accessory Products

Proteins and/or Positive Controls

Proteins for ABL1 / ABL2 (17 products)

Catalog No. Species Pres. Purity   Source  

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

ABL1

ABL1 Human
  Abnova Taiwan Corp.

Positive controls for ABL1 / ABL2 (2 products)

Catalog No. Species Pres. Purity   Source  

c Abl Lysate

Western Blot: c Abl Lysate [NBL1-07208] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for ABL1 Protein
  Novus Biologicals Inc.

c Abl Lysate

Western Blot: c Abl Lysate [NBL1-07209] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for ABL1 Protein
  Novus Biologicals Inc.
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