discontinued

NBP1-04932 ABL1 / ABL2 antibody

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0.1 mg / €360.00

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Rabbit anti Human, Mouse ABL1 / ABL2

Product Description for ABL1 / ABL2

Rabbit anti Human, Mouse ABL1 / ABL2.
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for ABL1 / ABL2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms ABL1 antibody, ABL2 antibody, Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody, Bcr/c abl oncogene protein antibody, JTK7 antibody, Transformation gene oncogene ABL antibody, c-ABL antibody, p150 antibody
Presentation Aff - Purified
Reactivity Hu, Ms
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
The antiserum was produced against synthesized non-phosphopeptide derived from human ABL1/2 around the phosphorylation site of tyrosine 393/429 (D-T-Yp-T-A).
Add. information Research Areas: Cancer
Application immunohistochemistry, This antibody is useful for immunohistochemistry 1:50-1:100, immunohistochemistry 1:50-1:100,
Background The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase. ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. It is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments.
Concentration 1 mg/ml
General Readings Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650.
Danial, N.N. et al. (2000) Oncogene 19, 2523-2531.
Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637.
Pluk, H. et al. (2002) Cell 108, 247-259.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
0.02% Sodium Azide
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Specificity:
ABL1/2 (Ab-393/429) detects endogenous levels of total ABL1/2 protein.
Species:
Human, Mouse

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