AP56092PU-N ACF7/MACF1a antibody

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Rabbit anti Human ACF7/MACF1a


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  • AP56092PU-N

Product Description for ACF7/MACF1a

Rabbit anti Human ACF7/MACF1a.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Dot blot, Immunocytochemistry/Immunofluorescence.

Properties for ACF7/MACF1a

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms 620 kDa actin-binding protein, ABP620, Actin cross-linking family protein 7, Macrophin-1, Microtubule-actin cross-linking factor 1, Trabeculin-alpha, isoforms 1/2/3/5
Presentation Aff - Purified
Reactivity Hu
Applications Dot, ICC/IF, P
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
KLH-conjugated linear peptide corresponding to human ACF7/MACF1a.
Application Immunocytochemistry: A 1:500 dilution from a representative lot detected ACF7/MACF1a in NIH/3T3 and HeLa cells.
Dot Blot.
Background Actin cross-linking family protein 7 (ACF7), also known as Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1a) exists as 5 different isoforms. Isoform 2, also known as MACF1a, serves as an F-actin-binding protein, which may play a role in cross-linking actin to other cytoskeletal proteins. In migrating cells, MACF1a localizes to the plasma membrane and ruffles in a GSK3-, Memo-, and APC-dependent manner. MACF1a localization is required for microtubule capture at the cell cortex downstream of ErbB2 signaling. Upon binding with AXIN1, beta-catenin, GSK3beta, and APC, MACF1a translocates this multi-complex from the cytoplasm to the cell membrane. MACF1a acts as a positive regulator of Wnt-induced TCF/beta-catenin-dependent transcriptional activation. It also plays an important role in wound healing, epidermal cellular migration, CNS development, and the polarization and coordinated movement of hair follicle stem cells.
Concentration lot-specific
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Affinity Chromatography
Buffer System:
0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Liquid purified Ig fraction
Aff - Purified
Demonstrated to react with Human. Other Homologies: Bovine (75% sequence homology).

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