discontinued

NB120-10598 Activin Receptor Like Kinase 1 antibody

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0.025 mg / €420.00

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Goat anti Human Activin Receptor Like Kinase 1

NB120-10598

Product Description for Activin Receptor Like Kinase 1

Goat anti Human Activin Receptor Like Kinase 1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Activin Receptor Like Kinase 1

Product Category Primary Antibodies
Quantity 0.025 mg
Synonyms ALK1
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant fragment (Human).
Background The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. Type II receptors are constitutively active kinases, which phosphorylate type I receptors after ligand binding. In turn, the activated type I kinases phosphorylate downstream signaling molecules including the various smads. Seven type I receptors, also termed activin receptor-like kinase (ALK), have been isolated from mammals. The physiological ligand for ALK1 is currently unknown. It is suggested that TGF-beta 1 and TGF-beta 3 can activate chimeric ALK1. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues. Mutations in ALK1 are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting an important role for ALK1 in the control of blood vessel development and repair.
Concentration 0.1 mg/ml
General Readings General / background references:de Winter JP et al. Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. Endocrinology 132:975-82 (1993). PubMed PMID: 7679985
Smith JC et al. Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67:79-87 (1991). PubMed PMID: 1717160
de Jong FH et al. Effects of factors from ovarian follicular fluid and Sertoli cell culture medium on in-vivo and in-vitro release of pituitary gonadotrophins in the rat: an evaluation of systems for the assay of inhibin. J Reprod Fertil Suppl :47-59 (1979). PubMed PMID: 293411
Format
Purification:
Immunogen affinity purified
Buffer System:
Preservative: NoneConstituents: PBS
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Cross-reacts with Human.Not yet tested in other species.

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