AP30021PU-N Adenovirus Type 9 (E4 Orf1) antibody

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0.1 mg / €360.00
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Quick Overview

Rabbit anti Adenovirus Type 9

AP30021PU-N

Product Description for Adenovirus Type 9

Rabbit anti Adenovirus Type 9.
Properties: (E4 Orf1)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay.

Properties for Adenovirus Type 9

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms AD9 E4 Orf1
Presentation Aff - Purified
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P89079
Immunogen:
Ad-9 E4 Orf1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of the Ad-9 E4 Orf1. (AP30021CP-N)
Property E4 Orf1
Control peptide AP30021CP-N
Add. information Blocking peptide available: blocking peptide (AP30021CP-N)
Application ELISA.
Background The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.
General Readings
  1. Shenk T. Adenoviridae: the viruses and their replication, p. 2265-2300 in DM Knipe and PM Howley (ed.) Fields virology, 4th ed. Vol. 2. 2001. Lippincott-Raven Publishers, Philadelphia, PA.
  2. Javier R, Rasha Jr. K, Macdonald GJ, et al. Human adenovirus type 9-induced rat mammary tumors. J. Virol. 1991; 65:3192-202.
  3. Javier RT. Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats. J Virol. 1994 Jun;68(6):3917-24. PubMed PMID: 8189528. (Free PMC Article available)
  4. Weiss RS, Lee SS, Prasad BV, Javier RT. Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes. J Virol. 1997 Mar;71(3):1857-70. PubMed PMID: 9032316. (Free PMC Article available)
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody reacts to Ad-9 E4 Orf1.

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