AP26374PU-N AGGF1 / VG5Q antibody

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0.1 mg / €440.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Mouse AGGF1 / VG5Q

AP26374PU-N

Product Description for AGGF1 / VG5Q

Rabbit anti Mouse AGGF1 / VG5Q.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Immunoprecipitation, Enzyme Immunoassay, Paraffin Sections, Frozen Sections.

Properties for AGGF1 / VG5Q

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Angiogenic factor VG5Q, Angiogenic factor with G patch and FHA domains 1, G patch domain-containing protein 7, GPATC7, GPATCH7, Vasculogenesis gene on 5q protein
Presentation Purified
Reactivity Ms
Applications C, E, IP, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q7TN31
GeneID:
66549
Application Immunohistochemistry on frozen sections: The typical starting working dilution is 1:10.
Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:10.
Immunoassays.
Immunoprecipitation.
Western blot: The typical starting working dilution is 1:10.
Background

VG5Q functions as an angiogenic factor in promoting angiogenesis and suppression of VG5Q expression inhibits vessel formation. Angiogenic factors are critical to the initiation of angiogenesis and maintenance of the vascular network. Angiogenesis has an essential role in pathological conditions such as cancer and various ischaemic and inflammatory diseases.
VG5Q can bind to endothelial cells and promote cell proliferation, suggesting that the protein may act in an autocrine fashion. VG5Q interacts with TWEAK (also known as TNFSF12), another secreted angiogenic factor.
VG5Q shows strong expression in blood vessels and is secreted when vessel formation is initiated. VG5Q protein was detected mostly in the cytoplasm and around the nuclei of human microvascular endothelial cells (HMVECs). Furthermore VG5Q is detected in human umbilical vein endothelial cells (HUVECs), human heart fibroblast (HHF) and ovarian cancer cells (OV-3), but low expression was detected in kidney cancer cells (RP-45), HeLa Cells and bladder cancer cells.

Concentration 0.1 mg/ml
General Readings
  1. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, et al. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature. 2004 Feb 12;427(6975):640-5. PubMed PMID: 14961121. (Free PMC Article available, 4 images available)
Storage Store at 2 - 8 °C.
Shelf life: one year from despatch.
Format
Purification:
Protein A
Buffer System:
PBS
Preservatives:
0.02% sodium azide
Stabilizers:
0.1% bovine serum albumin
State:
Liquid 0.2 µm filtered Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Mouse
Specificity
Specificity:
The polyclonal antibody reacts with mouse VG5Q, a 84 kDa protein.
Gene ID 66549

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