discontinued

SP5418P Aggrecan Neo antibody

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Search for all "Aggrecan Neo"

0.1 mg / €470.00

Quick Overview

Rabbit anti Bovine, Canine, Human, Mouse, Porcine, Rat Aggrecan Neo

SP5418P

Product Description for Aggrecan Neo

Rabbit anti Bovine, Canine, Human, Mouse, Porcine, Rat Aggrecan Neo.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Aggrecan Neo

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Bov, Can, Hu, Ms, Por, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic Peptide: C G G N I T E G E corresponding to amino acid residues from human aggrecan protein.
Application Western Blot: 1 µg/ml, detects an ~64 kDa protein representing the neoepitope sequence NITEGE generated by aggrecanase-mediated cleavage at Glu373-Ala374 of aggrecan core proteins).
Background Aggrecan is a member of large, aggregating proteoglycans (also including, versican, brevican and neurocan) found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMP's) and aggrecanase (ADAMTS). Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis.
The C-terminal NITEGE fragment is one of the G1 fragments produced when aggrecan is cleaved with aggrecanase. It is the most abundant fragment found in normal human synovial fluid and articular cartilage, and is the major product produced by aggrecanase cleavage. The NITEGE fragment has also been shown to accumulate rapidly after an acute cartilage injury.
Concentration 0.83 mg/ml
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography.
Buffer System:
PBS containing 1 mg/ml BSA and 0.05% sodium azide as preservative.
State:
Liquid purified Ig fraction.
Aff - Purified
Specificity
Specificity:
SP5418P detects human, rat, mouse, bovine, canine, and porcine aggrecan neo G1.

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