discontinued

SP5181P Aggrecan antibody

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0.1 mg / €460.00

Quick Overview

Rabbit anti Bovine, Human, Rat Aggrecan

Product Description for Aggrecan

Rabbit anti Bovine, Human, Rat Aggrecan.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Aggrecan

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Bov, Hu, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide corresponding to residues C A(89) T E G Q V R V N S I Y Q D K V S L(106) of human Aggrecan
Remarks:
This sequence is completely conserved between mouse and rat.
The immunizing peptide (SP5181CP) can be used for neutralization and control experiments.
Add. information This polyclonal antibody has been referred to as JSCATE or ATEGQV.
Application Western blot (1 µg/ml): detects an ~250 kDa protein representing aggrecan from rat chondrosarcoma cells.
Background Aggrecan is a member of the family of large aggregating proteoglycans (also including versican, brevican, and neurocan). There is evidence that this family pf proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS. A prominent feature in joint disease (such as rheumatoid arthritis and osteoarthritis) is a loss of aggrecan. Two major cleavage sites are present in the IGD-domain separating the G1 and G2 domains.
Concentration 0.59 mg/ml
General Readings J. Neurosci., 21(13): 4772-4781, 2001.
Biochem. J., 351: 161-166, 2000.
Storage Store the antibody at -20°C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
PBS containing 1 mg/ml BSA and 0.05% sodium azide
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
The antibody detects Aggrecan.
Species:
Human, rat, bovine.

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