discontinued

GTX24802 AKT pSer473 antibody

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50 µl / €380.00

Quick Overview

Rabbit anti Human, Mouse AKT

GTX24802

Product Description for AKT

Rabbit anti Human, Mouse AKT.
Properties: pSer473
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot, Paraffin Sections.

Properties for AKT

Product Category Primary Antibodies
Quantity 50 µl
Synonyms C-AKT, EC=2.7.11.1, PKB, Protein kinase B, RAC, RAC-PK-alpha, RAC-alpha Serine/Threonine-Protein Kinase
Presentation Aff - Purified
Reactivity Hu, Ms
Applications C, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide (Human) derived from the region of human AKT that contains serine 473. The sequence is conserved among multiple species including mouse and rat across the three isoforms, AKT1, AKT2, and AKT3.
Property pSer473
Application IHC-Fr, IHC-P, WB
Background AKT, also known as Protein Kinase B (PKB) or RAC alpha, is a 65 kDa serine/threonine kinase that plays an important role in many biological responses including metabolism, cell survival and growth by phosphorylating many proteins including GSK 3 beta, caspase 9, BAD, and the Forkhead Transcription Factor. AKT is activated by PI3 K, which in turn can interact with proteins such as Focal Adhesion Kinase (when Focal Adhesion Kinase is phosphorylated at Tyr397), thereby linking activation to the cytoskeleton. AKT is phosphorylated on Thr308 by PDK 1 and on Ser473 by PDK 2. Phosphorylation at Ser473 is required for full activation of AKT.
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium Azide; Constituents: 50% Glycerol, PBS, 1mg/ml BSA (IgG, protease free). pH 7.3
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
Cross-reacts with Human and Mouse. Expected to cross-react with a wide range of other species due to sequence homology. Not yet tested in other species.

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