NB100-1401 ALKB antibody

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Goat anti Human ALKB


Product Description for ALKB

Goat anti Human ALKB.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for ALKB

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms E. coli
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide: HIEQVFSPSASGK representing the N-Terminus of the human protein (residues 2-14) according to NP_006011.
Background **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application.

ALKB is a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. Repair of DNA damage is essential for maintaining genome integrity, and repair deficiencies in mammals are associated with cancer, neurological disease and developmental defects. Alkylation damage in DNA is repaired by at least three different mechanisms, including damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine by Escherichia coli AlkB.
Concentration 0.5 mg/ml
General Readings Aas PA et al. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421:859-63 (2003). PubMed PMID: 12594517
Immunogen affinity purified
Buffer System:
Tris-saline containing 0.02% Na azide (pH7.3) with 0.5% BSA
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human. Not yet tested in other species.

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