discontinued

NBP1-48612 alpha Catenin antibody

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Rabbit anti Human, Mouse alpha Catenin

Product Description for alpha Catenin

Rabbit anti Human, Mouse alpha Catenin.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for alpha Catenin

Product Category Primary Antibodies
Quantity 0.2 mg
Synonyms Anti-alpha catenin antibody, anti-CAP 102 antibody, anti-CAP102 antibody, anti-CTNNA 1 antibody, anti-CTNNA1 antibody, anti-Cadherin associated protein 102kDa antibody, anti-Cadherin associated protein antibody, anti-Catenin (cadherin associated protein) alpha 1, anti-Catenin alpha 1 antibody, anti-FLJ36832 antibody, anti-NY REN 13 antigen antibody, anti-alpha E catenin antibody, anti-alphaE catenin antibody
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8N1C0
Immunogen:
Synthesized non-phosphopeptide derived from human alpha-catenin around the phosphorylation site of serine 641 (D-D-S P -D-F).
Background The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Concentration 1.0 mg/ml
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
PBS (without Mg 2+ and Ca 2+), pH 7.4, 150mM NaCl, and 50% glycerol
State:
Aff - Purified

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