DDX0910A647-100 Alpha-Synuclein / SNCA antibody

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0.1 mg / €520.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human Alpha-Synuclein / SNCA AS11

DDX0910A647-100

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  • DDX0910A647-100

Product Description for Alpha-Synuclein / SNCA

Mouse anti Human Alpha-Synuclein / SNCA AS11.
Presentation: Alexa Fluor 647
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for Alpha-Synuclein / SNCA

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Presentation Alexa Fluor 647
Reactivity Hu
Applications ICC/IF
Clonality Monoclonal
Clone AS11
Host Mouse
Isotype IgG
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
P37840
Immunogen:
rhu α-synuclein (SIGMA).
GeneID:
6622
Application DDX0910P-50 / DDX0910P-100 Purified: ImmunoFluorescence, ImmunoHistoChemistry frozen sections, Western Blot. 
DDX0910A488-50 / DDX0910A488-100 Alexa-fluor®488: ImmunoFluorescence. 
DDX0910A546-50 / DDX0910A546-100 Alexa-fluor®546: ImmunoFluorescence.  
DDX0910A647-50 / DDX0910A647-100 Alexa-fluor®647: ImmunoFluorescence. 
DDX0910HRP-50 / DDX0910HRP-100 Horseradish Peroxydase: ImmunoHistoChemistry frozen sections, Western Blot. 

Usage recommendation:
*This monoclonal antibody may be used between 5-20 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Background α-synuclein (snca) is a140 aas neuronal protein predominantly present in synaptic junctions, specially studied for its relevance in understanding sporadic and familial forms of Parkinson’s disease and related neurodegenerative disorders. In an attempt to break the immunotolerance since the amino-acid sequence is highly conserved between species (95.3% homology between human and mouse), we have immunized C57BL/6 inbred mice presenting a natural deletion for snca with recombinant human α-synuclein and obtained a murine mAb (AS11) recognizing endogenous human α-synuclein. (Kahle et al.,2000, J Neurosci 2000;20:6365–73 ; Specht and Schoepfer, BMC Neurosci 2001;2:11 ; Mougenot AL et al, J Neurosci Methods. 2010 Oct 15;192(2):268-76).
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Mougenot AL, Bétemps D, Hogeveen KN, Kovacs GG, Chouaf-Lakhdar L, Milhavet O, et al. Production of a monoclonal antibody, against human α-synuclein, in a subpopulation of C57BL/6J mice, presenting a deletion of the α-synuclein locus. J Neurosci Methods. 2010 Oct 15;192(2):268-76. doi: 10.1016/j.jneumeth.2010.08.010. Epub 2010 Aug 13. PubMed PMID: 20709102.
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Format
Label:
Alexa Fluor 647
Purification:
QMA Hyper D ion exchange chromatography
Buffer System:
Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl Tris PBS 50% glycerol.
Specificity
Specificity:
N-terminal portion of Human α-synuclein (aa1-60)
Species cross-reactivity: Negative for Murine α-synuclein.

Accessory Products

Proteins and/or Positive Controls

Proteins for Alpha-Synuclein / SNCA (49 products)

Catalog No. Species Pres. Purity   Source  

Alpha-Synuclein / SNCA (transcript variant NACP140)

Alpha-Synuclein / SNCA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA (transcript variant NACP112)

Alpha-Synuclein / SNCA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA (transcript variant 2)

Alpha-Synuclein / SNCA Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA (transcript variant 3)

Alpha-Synuclein / SNCA Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA (full length, transcript variant 1)

Alpha-Synuclein / SNCA Human > 95 %
Preparation: .
Purity Detail: > 95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
0.1 mg / €399.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA (A30P Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (A30P Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140)

Alpha-Synuclein / SNCA Human Purified > 95 % pure by SDS-PAGE. E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140)

Alpha-Synuclein / SNCA Human Purified > 95 % E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140)

Alpha-Synuclein / SNCA Human Purified > 95 % pure by SDS-PAGE. E. coli
1 mg / €520.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140)

Alpha-Synuclein / SNCA Human Purified > 95 % E. coli
1 mg / €520.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (A53T Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (A53T Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (A30P/A53T Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (A30P/A53T Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (Delta-Nac Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (Delta-Nac Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (NACP112)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (NACP112)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (61-140)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (61-140)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE. E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (96-140)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (96-140)

Alpha-Synuclein / SNCA Human Purified > 95 % E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-60)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-60)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (E46K Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (E46K Mutant)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-95)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-95)

Alpha-Synuclein / SNCA Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human
  Abnova Taiwan Corp.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human
  Abnova Taiwan Corp.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human Purified
  Alpha Diagnostic Intl. Inc.

Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA Human Purified > 95 % E. coli
20 µg / €190.00
  Neuromics Antibodies

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-07002] - a-Synuclein, 14.4 kDa (140 aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18320] - a-Synuclein A30P, 14.4 kDa (140 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

Peptide ELISA: alpha Synuclein [A53T] Protein [NBC1-18321] - a-Synuclein A53T, 14.4 kDa (140 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18322] - a-Synuclein A30P/A53T, 14.5 kDa (140 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18323] - a-Synuclein, 11.9 kDa (111 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18324] - a-Synuclein, 11.3 kDa (112 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18325] - a-Synuclein, 8.4 kDa (81 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18326] - a-Synuclein, 5.2 kDa (46 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18327] - a-Synuclein, 6.1 kDa (60 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: beta Synuclein Protein [NBC1-18328] - 14.2 kDa (134 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18331] - a-Synuclein E46K, 14.4 (140 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Alpha-Synuclein / SNCA

SDS-Page: alpha Synuclein Protein [NBC1-18332] - a-Synuclein, 9.3 kDa (95 aa) , confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

Positive controls for Alpha-Synuclein / SNCA (4 products)

Catalog No. Species Pres. Purity   Source  

alpha Synuclein Lysate

Western Blot: alpha Synuclein Lysate [NBL1-16274] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for SNCA.
  Novus Biologicals Inc.

SNCA overexpression lysate

SNCA overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.

SNCA overexpression lysate

SNCA overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.

SNCA overexpression lysate

SNCA overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.
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