SM6205P Amyloid Beta (1-11) antibody

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Mouse anti Human Amyloid Beta (1-11) 57A8


Product Description for Amyloid Beta (1-11)

Mouse anti Human Amyloid Beta (1-11) 57A8.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Amyloid Beta (1-11)

Product Category Primary Antibodies
Quantity 50 µg
Presentation Purified
Reactivity Hu
Applications C, E, ICC/IF, WB
Clonality Monoclonal
Clone 57A8
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Synthetic peptide corresponding to amino acids 672-683 of Amyloid protein derived from the full-length beta-amyloid precursor protein of human origin.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Immunohistochemistry (1/100, 10 min at room temperature), Western blotting
(0.5 - 2 µg/ml, the antibody can be used for detection of 4 kDa A beta) and ELISA
(0.1 - 1-0 µg/ml, the antibody is specific to beta-Amyloid (1-11). Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
General Readings
  1. Ainha S et al (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 11049-11053.
  2. Haass, C. et al (1993) Cell 75, 1039-1042.
  3. Busciglio J et al (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 2092-2096.
  4. Shoji M et al (1992) Science, 258, 126-129.
  5. Suzuki N et al (1994) Science, 264, 1336-1340.
  6. Dewachter I et al (2000), J. Neuroscien
Storage Store the antibody undiluted at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf life: one year from despatch.
Alzheimer's Disease (AD) is characterized by the deposits
of the 4-kDa amyloid beta peptide (Aβ) (1-2). The amyloid beta protein precursor (APP) is cleaved by beta-secretase to generate a C-terminal fragment, CTFβ, which in turn is cleaved by γ-secretase to generate Aβ. The Aβ is proposed to play an important in Alzheimer's disease. Normal neuronal cells constitutively secrete Aβ, which is detected in cerebrospinal fluid and blood (3). The length of most the secreted Aβ molecule is 40 residues (Aβ40) (4), but a small fraction (10%) is 42 residues long (Aβ42) (5). Both Aβ40 and Aβ42 peptides increase with aging (6).
This antibody reacts with human beta amyloid (1-11).

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