AM00790PU-N Amyloid beta (1-43 specific) antibody

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Mouse anti Human Amyloid beta 9C4


Product Description for Amyloid beta

Mouse anti Human Amyloid beta 9C4.
Properties: (1-43 specific)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot, Paraffin Sections.

Properties for Amyloid beta

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Purified
Reactivity Hu
Applications E, P, WB
Clonality Monoclonal
Clone 9C4
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Peptide corresponding to the last 6 amino acids of ABx-43 coupled to KLH through the addition of an N-terminal cysteine.
Property 1-43 specific
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Western blot: 1:100 - 1:1,000.
ELISA: >1:500.
Immunohistochemistry on paraffin sections: 1:100 - 1:500; For optimal staining, sections should be pretreated with formic acid (70%) for 10 - 30 minutes; Antibody should be incubated with the sections overnight at 2 - 8°C.
Background Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver; ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri; moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Concentration 0.5mg/ml (OD280nm)
General Readings Parvathy, S., et al., (2001), Correlation between ABx-40-, ABx-42-, and ABx-43- containing amyloid plaques and cognitive decline, Arch. Neurol., 58, 2025–2032.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein A chromatography
Buffer System:
Liquid purified IgG
This antibody is reactive to the C-terminus of beta amyloid and specific for the isoform ending at the 43rd amino acid.
Gene ID 351

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