AM26397PU-L Amyloid beta (N-term) antibody

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0.5 mg / €430.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human Amyloid beta NT 7H7

AM26397PU-L

Product Description for Amyloid beta

Mouse anti Human Amyloid beta NT 7H7.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for ELISA (capture), Enzyme Immunoassay.

Properties for Amyloid beta

Product Category Primary Antibodies
Quantity 0.5 mg
Presentation Aff - Purified
Reactivity Hu
Applications E, E(capture)
Clonality Monoclonal
Clone NT 7H7
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Full length human beta amyloid peptide 42
Property N-term
Application ELISA: Capture antibody to detect A beta 42 or A beta 40 in sandwich ELISA. The matched detection antibody clones are: CA9 10C11 for A beta 42 assay, and CV9 7B10 for A beta 40 assay.
Background Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.
Storage

Store at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Protein G affinity purified
Buffer System:
0.01M PBS pH7.2
State:
Lyophilized Ig fraction
Aff - Purified
Reconstitution:
Use double distillated water to reconstitute the antibody.
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:

This antibody recognizes the N-terminal sequence (DAEFRHDS) of beta amyloid peptides, and full length beta amyloid peptide 40, 42 and 43.

Gene ID 351

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