AP31731PU-N Amyloid Fibrils (OC) antibody

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0.1 ml / €370.00
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Rabbit anti Human Amyloid Fibrils (OC)

AP31731PU-N

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Product Description for Amyloid Fibrils (OC)

Rabbit anti Human Amyloid Fibrils (OC).
Presentation: Purified
Product is tested for Frozen Sections, Dot blot, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for Amyloid Fibrils (OC)

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Fibrils, OC
Presentation Purified
Reactivity Hu
Applications C, Dot, E, ICC/IF, IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Fibrils prepared from Human Aß42 peptide.
Application Dot Blot: 1/1000.
A 1/1000 dilution of AP31731PU-N was sufficient for detection of Amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-Rabbit IgG:HRP as the secondary antibody.
Cited Applications: 
ELISA, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry and Western Blot, Dot Blot.
Background Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease (2, 3).
Product Citations
Originator or purchased from resellers:
  1. Nakajima H, Nishitsuji K, Kawashima H, Kuwabara K, Mikawa S, Uchimura K, et al. The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity. Amyloid. 2016 Mar;23(1):17-25. doi: 10.3109/13506129.2015.1113167. Epub 2015 Dec 24. PubMed PMID: 26701221.
  2. Nakajima H, Nishitsuji K, Kawashima H, Kuwabara K, Mikawa S, Uchimura K, et al. The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity. Amyloid. 2016 Mar;23(1):17-25. doi: 10.3109/13506129.2015.1113167. Epub 2015 Dec 24. PubMed PMID: 26701221.
  3. Tang Z, Dai S, He Y, Doty RA, Shultz LD, Sampson SB, et al. MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1. Cell. 2015 Feb 12;160(4):729-44. doi: 10.1016/j.cell.2015.01.028. PubMed PMID: 25679764. (Free PMC Article available)
General Readings
  1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.
  2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366.
  3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Protein A Chromatography
Buffer System:
PBS
Preservatives:
0.09% Sodium Azide
Stabilizers:
50% Glycerol
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody recognizes generic epitopes common to many Amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins.

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