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AP31729PU-N Amyloid Oligomers (A11) antibody

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0.1 mg / €370.00

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Rabbit anti Human, Mouse, Rat Amyloid Oligomers (A11)

AP31729PU-N

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  • AP31729PU-N

Product Description for Amyloid Oligomers (A11)

Rabbit anti Human, Mouse, Rat Amyloid Oligomers (A11).
Presentation: Purified
Product is tested for Frozen Sections, Dot blot, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for Amyloid Oligomers (A11)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms A11, Amyloid Oligomer AlphaBeta, amyloid, oligomers
Presentation Purified
Reactivity Eukaryotes, Hu, Ms, Rt
Applications C, Dot, E, ICC/IF, IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic molecular mimic of soluble oligomers.
Application ELISA and Dot Blot (0.1-10 µg/ml).
Western Blot: 1/1000.
Immunofluorescence.
Immunoprecipitation: (1/1000).
Immunohistochemitry: (1/1000-1/10,000).
Certificate of Analysis: A 1/1000 dilution of AP31729PU-N was sufficient for detection of amyloid oligomers in 10 μg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-Rabbit IgG:HRP as the secondary antibody.
Background Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease (2, 3).
Concentration 1 mg/ml
General Readings
  1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.
  2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366.
  3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A purified
Buffer System:
PBS
Preservatives:
0.09% Sodium Azide
Stabilizers:
50% Glycerol
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse and Rat.
Specificity
Specificity:
Recognizes all types of Amyloid oligomers.
Appears to recognize a peptide backbone epitope that is common to Amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Species:
Not species specific. 
Reacts with Eukaryots. 

Gene ID 351

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