discontinued

NB100-62349 Angiotensin III antibody

See related secondary antibodies

Search for all "Angiotensin III"

1 ml / €390.00

Quick Overview

Rabbit anti Human Angiotensin III

NB100-62349

Product Description for Angiotensin III

Rabbit anti Human Angiotensin III.
Product is tested for Enzyme Immunoassay.

Properties for Angiotensin III

Product Category Primary Antibodies
Quantity 1 ml
Synonyms ANG-3, ANG-III, ANG3, Angiotensin-3, Angiotensin-III, Des-Asp[1]-angiotensin II, alpha 1 antiproteinase antitrypsin, serine or cysteine
Reactivity Hu
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
RSA/RaIg conjugated
Application ELISA, This antibody is useful for ELISA, ELISA 1/500 - 1/2000
Background Angiotensin III is an eptapeptide drived from cleavage of full length angiotensin (AGT). AGT is a polypeptide vasopressor hormone formed by the catalytic action of renin, which is released mainly by the kidneys in response to low blood volume or low sodium content in the body. The juxtaglomerular cells release renin when juxtaglomerular apparatus decreases in the kidneys. Renin (called angiotensinogenase) is an enzyme of the hydrolase class that catalyzes cleavage of the leucine leucine bond in angiotensinogen (a serum globulin) to generate angiotensin I in the liver. Angiotensin I acts mainly as a precursor to angiotensin II, which is a vasopressor and stimulator of aldosterone secretion by the adrenal cortex, and also functions as a neurotransmitter. Angiotensin III (heptapeptide) is a degradation product of angiotensin II, and has less vasopressor activity than the parent compound. However, Angiotensin III does stimulate aldosterone release. The renin-angiotensin system plays an important role in the regulation of blood volume and blood pressure, stimulates antidiuretic hormone and aldosterone production, and the hypothalamus to activate the thirst reflex, but is crucial in the pathogenesis of hypertension patients due to blood vessels constrict, retention of fluid and raising blood pressure.
Concentration 0.37 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Buffer System:
0.09% Sodium Azide
Specificity
Specificity:
R-V-Y-I-H-P-F, NB100-62349 is specific for Angiotensin III, and shows the following cross-reactivities with other forms of Angiotensin: Angiotensin II <25%, Angiotensin I <10%. Angiotensin III is formed by cleavage of the N-terminal aspartic acid residue of Angiotensin II, and plays a major part in the regulation of vasopressin secretion.
Species:
Human

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