NB100-94430 Anthrax LF antibody

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Rabbit anti Bacteria Anthrax LF


Product Description for Anthrax LF

Rabbit anti Bacteria Anthrax LF.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Anthrax LF

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Bac
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rabbit anti-Anthrax LF protein polyclonal antibody was raised against a synthetic peptide corresponding to 16 amino acids near the carboxy-terminus of the Anthrax lethal factor protein (Genbank accession no. P15917).
Add. information Research Areas: Immunology
Application ELISA, This polyclonal antibody can be used for the detection of Anthrax LF protein in ELISA. It will detect 10 ng of free peptide at 1 ug/ml., ELISA,
Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) (1,2 for review). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) (3) and capillary morphogenesis protein 2 (CMG2) (4), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm (5). LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis (6).
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
0.02% Sodium Azide
IgG purified
Anthrax LF

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