NB100-94427 Anthrax PA antibody

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Rabbit anti Bacteria Anthrax PA


Product Description for Anthrax PA

Rabbit anti Bacteria Anthrax PA.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Anthrax PA

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Bac
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rabbit anti-Anthrax PA protein polyclonal antibody was raised against a synthetic peptide corresponding to 16 amino acids in the middle of the Anthrax protective antigen protein (Genbank accession no. AAF86457).
Add. information Research Areas: Immunology
Application ELISA, This polyclonal antibody can be used for the detection of Anthrax PA protein in ELISA. It will detect 10 ng of free peptide at 1 ug/ml., ELISA,
Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) (1,2 for review). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) (3) and capillary morphogenesis protein 2 (CMG2) (4), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm (5). These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
0.02% Sodium Azide
IgG purified
Anthrax PA

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