AP13314PU-N APH1A (N-term) antibody

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0.4 ml / €370.00
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Rabbit anti Human APH1A

AP13314PU-N

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  • AP13314PU-N

Product Description for APH1A

Rabbit anti Human APH1A.
Properties: (N-term)
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for APH1A

Product Category Primary Antibodies
Target Category
Quantity 0.4 ml
Synonyms APH-1A, Aph-1 alpha, CGI-78, Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor, aph-1
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q96BI3
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human APH1.
GeneID:
51107
Property N-term
Application ELISA: 1/1,000.
Western blotting: 1/100 - 1/500.
Immunohistochemistry: 1/50 - 1/100.
Background APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration lot specific
General Readings
  1. Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
  2. Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
  3. Marlow, L., et al., Biochem. Biophys. Res. Commun. 305(3):502-509 (2003).
  4. Kimberly, W.T., et al., Proc. Natl. Acad. Sci. U.S.A. 100(11):6382-6387 (2003).
  5. Edbauer, D., et al., Nat. Cell Biol. 5(5):486-488 (2003).
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody reacts to APH1.
Species:
Human.
Gene ID 51107

Accessory Products

Proteins and/or Positive Controls

Proteins for APH1A (1 products)

Catalog No. Species Pres. Purity   Source  

APH1A

APH1A Human
  Abnova Taiwan Corp.

Positive controls for APH1A (1 products)

Catalog No. Species Pres. Purity   Source  

APH1A overexpression lysate

APH1A overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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