NB100-56212 APIP1/2 antibody

See related secondary antibodies

Search for all "APIP1/2"

Quick Overview

Rabbit anti Human APIP1/2


Product Description for APIP1/2

Rabbit anti Human APIP1/2.
Presentation: Serum
Product is tested for Enzyme Immunoassay.

Properties for APIP1/2

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Reactivity Hu
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Background The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1) (1,2). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Whole antisera
Buffer System:
Rabbit sera with 50% glycerol and 0.025% sodium azide
Whole antisera
Human Not yet tested in other species.

Accessory Products

  • LinkedIn