discontinued

NB100-56211 APIP2 antibody

See related secondary antibodies

Search for all "APIP2"

0.1 ml / €380.00

Quick Overview

Rabbit anti Human APIP2

NB100-56211

Product Description for APIP2

Rabbit anti Human APIP2.
Presentation: Serum
Product is tested for Enzyme Immunoassay.

Properties for APIP2

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Reactivity Hu
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Background The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1) (1,2). Apaf 1 binds to cytochrome c (Apaf2) and Caspase-9 (Apaf3), which leads to Caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Format
Purification:
Whole antisera
Buffer System:
Rabbit sera with 50% glycerol and 0.025% sodium azide
Purity:
Whole antisera
State:
Serum
Specificity
Species:
Human Not yet tested in other species.

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