NB100-56814 Apoptosis-Inducing Factor (AIF) antibody

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Rabbit anti Human, Mouse, Rat Apoptosis-Inducing Factor (AIF)


Product Description for Apoptosis-Inducing Factor (AIF)

Rabbit anti Human, Mouse, Rat Apoptosis-Inducing Factor (AIF).
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay.

Properties for Apoptosis-Inducing Factor (AIF)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Apoptosis-Inducing Factor 1 Mitochondrial, Programmed Cell Death Protein 8 Mitochondrial
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

This antibody was developed against a synthetic peptide corresponding to amino acids 593-606 of human AIF. ([BLAST]QLDLKTFEFNKELRYL[/BLAST]); Genbank accession no. NP_004199.1. This sequence is present in human AIF isoforms 1, 2, and 3. Additionally, this peptide sequence is reported by NCBI to be 100% conserved between human, mouse and rat AIF.
Background . Apoptosis-inducing factor (AIF) is a phylogenetically ancient mitochondrial intermembrane flavoprotein (reviewed in 1 and 2). Recombinant AIF induces caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation when added to purified nuclei. Upon apoptosis induction, AIF translocates to the cytosol and the nucleus.
Affinity Purified
Buffer System:
PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Affinity Purified
Aff - Purified
Mouse, Human, Rat Not yet tested in other species.

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