discontinued

SP6270P ARC (Apoptosis Repressor with CARD) (191-208) antibody

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50 µg / €210.00

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Rabbit anti Human ARC (Apoptosis Repressor with CARD) (191-208)

SP6270P

Product Description for ARC (Apoptosis Repressor with CARD) (191-208)

Rabbit anti Human ARC (Apoptosis Repressor with CARD) (191-208).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for ARC (Apoptosis Repressor with CARD) (191-208)

Product Category Primary Antibodies
Quantity 50 µg
Synonyms AB2002, Nop30
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Immunogen
Immunogen:
A peptide corresponding to amino acids 191 to 208 of human origin (1).






Format: This antibody is supplied as liquid immunoaffinity chromatography purified immunglobulin fraction in Phosphate buffered saline with 0.02% sodium azide as preservative.
Application Suitable for wesern blot (1/1000, whole cell lysate from HeLa cells can be used as positive control and an approximately 25 kDa band can be detected). Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings
  1. Koseki T, Inohara N, Chen S, Núñez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5156-60. PubMed PMID: 9560245. (Free PMC Article available, 5 images available)
Storage Store the antibody undiluted at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf life: one year from despatch.
Format
State:
Aff - Purified
Specificity
Specificity:
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
This antibody reacts with human ARC (CT).

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