NB110-75102 ARC antibody

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Sheep anti Human, Mouse, Rat ARC


Product Description for ARC

Sheep anti Human, Mouse, Rat ARC.
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for ARC

Product Category Primary Antibodies
Quantity 0.5 mg
Presentation Purified
Reactivity Hu, Ms, Rt
Applications C, WB
Clonality Polyclonal
Host Sheep
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptides (a pentamer) as parts of human, mouse and rat Arg3.1 (ARC) was used as the immunogen.
Application immunohistochemistry, Western Blot
Background FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.
General Readings
  1. Tan J, et al. Neuroscience. 16;145(2):715-26(2007).
  2. Link,W, et al. Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5734-5738 (1995).
  3. Shepherd J.D, et al. Neuron 52:475-484(2006).
  4. Rial Verde E.M, et al. Neuron 52:461-474(2006).
  5. Chowdhury S, et al. Neuron 52:445-459(2006).
Storage Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1)
IgG purified
Buffer System:
Lyophilised in PBS
IgG purified
Human, mouse and rat. Other species not yet tested.

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