discontinued

AP30082PU-N ARTS antibody

See related secondary antibodies

Search for all "ARTS"

0.1 mg / €360.00

Quick Overview

Rabbit anti Human ARTS

AP30082PU-N

More Views

  • AP30082PU-N
  • AP30082PU-N

Product Description for ARTS

Rabbit anti Human ARTS.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for ARTS

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9H315
Immunogen:
Human ARTS Peptide (AP30082CP-N)
GeneID:
5414
Control peptide AP30082CP-N
Add. information Blocking peptide available: blocking peptide (AP30082CP-N)
Application ELISA.
Western Blot: ARTS antibody can be used for detection of ARTS at 0.5 to 2 μg/ml. Human lung, kidney and spleen tissue lysates can be used as a positive control and a band at 32 kDa can be detected.
Immunohistochemistry.
Background Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
General Readings
  1. Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol. 2000 Dec;2(12):915-21. PubMed PMID: 11146656.
  2. Depraetere V. The ARTS of apoptosis. Nat Cell Biol. 2000;2(12):E219.
  3. Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics. 1999 Jan 1;55(1):122-5. PubMed PMID: 9889007.
  4. Zieger B, Tran H, Hainmann I, Wunderle D, Zgaga-Griesz A, Blaser S, et al. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Gene. 2000 Dec 31;261(2):197-203. PubMed PMID: 11167005.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
ARTS antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.
Species:
Human.
Gene ID 5414

Accessory Products

  • LinkedIn