TA306101 ARTS antibody

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0.1 mg / €325.00
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Rabbit anti Human ARTS

TA306101

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  • TA306101
  • TA306101

Product Description for ARTS

Rabbit anti Human ARTS.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for ARTS

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9H315
Immunogen:
Human ARTS Peptide (AP30082CP-N)
GeneID:
5414
Add. information Blocking peptide available: blocking peptide (AP30082CP-N)
Application ELISA.
Western Blot: ARTS antibody can be used for detection of ARTS at 0.5 to 2 μg/ml. Human lung, kidney and spleen tissue lysates can be used as a positive control and a band at 32 kDa can be detected.
Immunohistochemistry.
Background Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
General Readings
  1. Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol. 2000 Dec;2(12):915-21. PubMed PMID: 11146656.
  2. Depraetere V. The ARTS of apoptosis. Nat Cell Biol. 2000;2(12):E219.
  3. Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics. 1999 Jan 1;55(1):122-5. PubMed PMID: 9889007.
  4. Zieger B, Tran H, Hainmann I, Wunderle D, Zgaga-Griesz A, Blaser S, et al. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Gene. 2000 Dec 31;261(2):197-203. PubMed PMID: 11167005.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
ARTS antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.
Species:
Human.

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