SP6281P ASC / TMS1 (182-195) antibody

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Rabbit anti Human ASC / TMS1 (182-195)


Product Description for ASC / TMS1 (182-195)

Rabbit anti Human ASC / TMS1 (182-195).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for ASC / TMS1 (182-195)

Product Category Primary Antibodies
Quantity 50 µg
Synonyms AB8394
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Rabbit anti-ASC/TMS1 polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 182 to 195 of human ASC (1).
Application This polyclonal antibody can be used for detection of ASC/TMS1 by Western blot at 1 μg/ml. HL60 whole cell lysate can be used as positive control and an approximately 25 kDa band can be detected. It is human reactive.
Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings 1. Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, HidakaE, Katsuyama T, Higuchi T, Sagara J. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1999;274(48): 33835-8.
2. Masumoto J, Taniguchi S, Nakayama K, Ayukawa K, Sagara J. Murine Ortholog of
ASC, a CARD-Containing Protein, Self-Associates and Exhibits Restricted Distribution in Developing Mouse Embryos. Exp Cell Res. 2001;262(2): 128-133.
3. Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res. 2000;60(22): 6236-42.
4. McConnell BB, Vertino PM. Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. Can
Storage Store the antibody at 2-8°C. Shelf life: one year from despatch
Aff - Purified
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (1-3). Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1 induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2)

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