DM334P ATM antibody

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Mouse anti Human, Mouse ATM ATX08


Product Description for ATM

Mouse anti Human, Mouse ATM ATX08.
Presentation: Purified
Product is tested for Frozen Sections, Paraffin Sections.

Properties for ATM

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms AB2354
Presentation Purified
Reactivity Hu, Ms
Applications C, P
Clonality Monoclonal
Clone ATX08
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Biomeda

Datasheet Extract

Recombinant human ATM protein
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Immunohistology (Formalin/Paraffin): Use Ab at 1-2µg/ml for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Recommended positive control: Breast Carcinomas.
Not suitable for Western Blotting.
Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.2 mg/ml
General Readings
  1. Knittweis J: Med Hypotheses 1998;51(1):53-57.
  2. Crawford TO: Semin Pediatr Neurol 1998 Dec;5(4):287-294.
  3. Knittweis J. An ataxia telangiectasia model: inefficient cell differentiation and possible reversal by serine protease inhibitors, tumor necrosis factor inhibitors, dexamethasone, and glutathione enhancers. Med Hypotheses. 1998 Jul;51(1):53-7. PubMed PMID: 9881837.
  4. Crawford TO: Ataxia telangiectasia. Semin Pediatr Neurol 1998 Dec;5(4):287-294.
  5. Takeuchi S, Koike M, Park S, Seriu T, Bartram CR, Taub HE, Williamson IK, Grewal J, Taguchi H, Koeffler HP: The ATM gene and susceptibility to ch ildhood Tcell acute lymphoblastic leukaemia. Br J Haematol 1998 Nov;103(2):536-538.
  6. Barlow C, Liyanage M, Moens PB, Tarsounas M, Nagashima K, Brown K, et al. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development. 1998 Oct;125(20):4007-17. PubMed PMID: 9735362.
  7. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, et al. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet. 1998 Dec;20(4):398-400. PubMed PMID: 9843217.
  8. Shiloh Y. Ataxia-telangiectasia, ATM and genomic stability: maintaining a delicate balance. Two international workshops on ataxia-telangiectasia, related disorders and the ATM protein. Biochim Biophys Acta. 1998 Oct 14;1378(2):R11-8. PubMed PMID: 9823376.
  9. Takagi M, Delia D, Chessa L, Iwata S, Shigeta T, Kanke Y, et al. Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia. Cancer Res. 1998 Nov 1;58(21):4923-9. PubMed PMID: 9810001.
  10. Westphal CH, Hoyes KP, Canman CE, Huang X, Kastan MB, Hendry JH, et al. Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res. 1998 Dec 15;58(24):5637-9. PubMed PMID: 9865712.
  11. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 1998 Sep 11;281(5383):1674-7. PubMed PMID: 9733514.
  12. Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7. PubMed PMID: 9836640.
  13. Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, et al. A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J Sci Am. 1998 Nov-Dec;4(6):385-9. PubMed PMID: 9853138.
Storage Store the antibody at 4°C. Do not freeze! Shelf life: one year from despatch.
Reacts with Breast Carcinomas. Ataxia telangiectasia (AT) (ATM - for AT mutated) is a rare genetic multisystem recessive disorder. Recombinant ATM protein phosphorylates p53 on serine 15 near the N-terminus, thereby contributing to the activation and stabilization of p53 during the IR. Reacts with Human and Mouse. Others not tested. Cellular Localization: nuclear.

Mol. Wt of Antigen: 350kD

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