discontinued

AP30104PU-N Avian Influenza Hemagglutinin 4 antibody

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0.1 mg / €360.00

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anti Avian Influenza Hemagglutinin 4

AP30104PU-N

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  • AP30104PU-N

Product Description for Avian Influenza Hemagglutinin 4

anti Avian Influenza Hemagglutinin 4.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay.

Properties for Avian Influenza Hemagglutinin 4

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms AFHA-4, Avian flu hemagglutinin, Avian influenza H5
Presentation Aff - Purified
Applications E
Clonality Polyclonal
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Avian Influenza Hemagglutinin 4 antibody was raised against a synthetic peptide corresponding to 10 amino acids near the center of the Hemagglutinin protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen. (AP30104CP-N)
Add. information Blocking peptide available: blocking peptide (AP30104CP-N)
Application Western Blot.
ELISA: It will detect 10 ng of free peptide at 1 μg/ml.
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.
General Readings
  1. Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. 2003 Jan 8;289(2):179-86. PubMed PMID: 12517228.
  2. Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol. 2000; 74:3-13.
  3. Shortridge KF, Zhou NN, Guan Y, Gao P, Ito T, Kawaoka Y, et al. Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology. 1998 Dec 20;252(2):331-42. PubMed PMID: 9878612.
  4. Iwatsuki-Horimoto K, Kanazawa R, Sugii S, Kawaoka Y, Horimoto T. The index influenza A virus subtype H5N1 isolated from a human in 1997 differs in its receptor-binding properties from a virulent avian influenza virus. J Gen Virol. 2004 Apr;85(Pt 4):1001-5. PubMed PMID: 15039542.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody reacts to Avian Influenza Hemagglutinin 4.

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