discontinued

AP09905PU-N AXL / UFO (843-864) antibody

See related secondary antibodies

Search for all "AXL / UFO"

Quick Overview

Rabbit anti Human, Monkey, Mouse, Rat AXL / UFO

AP09905PU-N

Product Description for AXL / UFO

Rabbit anti Human, Monkey, Mouse, Rat AXL / UFO.
Properties: (843-864)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for AXL / UFO

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Tyrosine-protein kinase receptor UFO
Presentation Aff - Purified
Reactivity Hu, Mky, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P30530
Immunogen:
Peptide selected from position 843-864
GeneID:
558
Property 843-864
Application ELISA.
Western blot 1:500.
Background Axl, also known as UFO, Tyro 7 and ARK, is a receptor tyrosine kinase, is involved in cell survival, proliferation, and migration and have sequence homology with other 2 members of the receptor tyrosine kinase family, MER and Tyro3. This tyrosine kinase is activated by the Growth Arrest Gene 6 (GAS 6) that binds and activated the kinase domin of this receptor kinase. Based on sequence homology and secondary structure predictions, AXL putative protein has a tyrosine kinase domain with unique 2 immunoglobulin like domain in the C-terminal end. It also has 2 fibronectin type III domains which are found on proteins such as receptor tyrosine phosphatases, and cell adhesion molecules. The expression of mRNA for this gene was noted in broad spectrum of developing tissues (e.g. subepidermal cells of the skin, mesenchymal cells of the periosteum). AXL expression is also detected in most cell lines and adult tissues except those of the hmatopoietic lineage (1, 2). The receptor Axl is expressed in primary prostate carcinoma and in prostate cancer cell lines as such as PC-3 and DU 145.

Axl expression increases in the neointima of balloon-injured rat carotids due to the oxidative stress which also plays a role in remodeling of injured vessels. Several cancer cell lines express Axl protein including primary prostate carcinoma and in prostate cancer cell lines as such as PC-3 and DU 145, myeloid leukemia. GAS 6 activation of Axl is also invloved in experimental nephritis model and spermatogenesis (3). IN testis, AXL is expressed in sertoli and leydig cell of the mature testis. The receptor tyrosine kinase AXL protein has has at least 2 variants (AXL1, AXL 2) and is a approximately 130 kDa (888 amino acids) protein. The AXL protein has simlar functional domins as its other family members and has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites.
Concentration 0.65 - 1.25 mg/ml (lot specific)
General Readings 1. Rescigno J, Mansukhani A, Basilico C. A putative receptor tyrosine kinase with unique structural topology. Oncogene. 1991 Oct;6(10):1909-13.
2. Sainaghi PP, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi GC. Gas6 induces proliferation in prostate carcinoma cell lines expressing the
Axl receptor. J Cell Physiol. 2005 Jul;204(1):36-44.
Storage Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
Stabilization buffer
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Monkey, Mouse, Rat
Specificity
Specificity:
This antibody detects a single 130kDa AXL protein. The antibody also reacts weakly to a 45 kDa protein in rat testis extracts.
Gene ID 558

Accessory Products

Proteins and/or Positive Controls

Proteins for AXL / UFO (14 products)

Catalog No. Species Pres. Purity   Source  

AXL / UFO (transcript variant 1)

AXL / UFO Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

AXL / UFO (C-term DDK/His tag, transcript variant 1)

AXL / UFO Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

AXL / UFO (C-term DDK/His tag, transcript variant 2)

AXL / UFO Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

AXL / UFO

AXL / UFO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human Purified
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human
  Abnova Taiwan Corp.

AXL / UFO

AXL / UFO Human
  Abnova Taiwan Corp.

Positive controls for AXL / UFO (4 products)

Catalog No. Species Pres. Purity   Source  

AXL 293T Cell Transient Overexpression Lysate(Denatured)

AXL 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

Axl Lysate

Western Blot: Axl Lysate [NBL1-07869] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for AXL Protein
  Novus Biologicals Inc.

AXL overexpression lysate

AXL overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

AXL / UFO Lysate (Non-Denatured)

AXL / UFO Lysate (Non-Denatured) Transient overexpression cell lysate was tested with Anti-AXL antibody (H00000558-M01) by Western Blots.
  Abnova Taiwan Corp.
  • LinkedIn