SM1659 Axonal Growth Cones antibody

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2 ml / €520.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Chicken, Human, Mouse, Rat Axonal Growth Cones 2G13

Product Description for Axonal Growth Cones

Mouse anti Chicken, Human, Mouse, Rat Axonal Growth Cones 2G13.
Presentation: Supernatant
Product is tested for Frozen Sections, Western blot / Immunoblot, Paraffin Sections.

Properties for Axonal Growth Cones

Product Category Primary Antibodies
Quantity 2 ml
Synonyms Growth Cone Marker
Presentation Supernatant
Reactivity Chk, Hu, Ms, Rt
Applications C, P, WB
Clonality Monoclonal
Clone 2G13
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Embryonic chick tectal membranes.
Spleen cells from immunised mice were fused with cells of the mouse NS1 myeloma cell line.
Application Immunohistochemistry on Frozen Sections.
Immunohistochemistry on Paraffin Sections.
Protein digestion pretreatment of paraffin sections not required.
Antigen retrieval using heat treatment prior to staining of paraffin sections not required.
Clone 2G13 has also been reported to work in Western Blotting.
Background Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kDa laminin receptor precursor or Laminin receptor 1 (Baloui et al. 2004). 40S ribosomal protein SA is a 296 amino acid ~37kDa membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor (UniProt: P50890). In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture (Stettler et al. 1999).
40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility (Stettler et al. 1999).
General Readings
  1. Stettler O, Bush MS, Kasper M, Schlosshauer B, Gordon-Weeks PR. Monoclonal antibody 2G13, a new axonal growth cone marker. J Neurocytol. 1999 Dec;28(12):1035-44. PubMed PMID: 11054903.
  2. Baloui H, von Boxberg Y, Vinh J, Weiss S, Rossier J, Nothias F, et al. Cellular prion protein/laminin receptor: distribution in adult central nervous system and characterization of an isoform associated with a subtype of cortical neurons. Eur J Neurosci. 2004 Nov;20(10):2605-16. PubMed PMID: 15548204.
  3. Espejo C, Penkowa M, Demestre M, Montalban X, Martínez-Cáceres EM. Time-course expression of CNS inflammatory, neurodegenerative tissue repair markers and metallothioneins during experimental autoimmune encephalomyelitis. Neuroscience. 2005;132(4):1135-49. PubMed PMID: 16078373.
  4. Kim SR, Chen X, Oo TF, Kareva T, Yarygina O, Wang C, et al. Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration. Ann Neurol. 2011 Jul;70(1):110-20. doi: 10.1002/ana.22383. Epub 2011 Mar 17. PubMed PMID: 21437936. (Free PMC Article available, 5 images available)
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
0.09% Sodium Azide
Liquid Tissue Culture Supernatant
This antibody recognizes intracellular 2G13P which is localized to Growth Cones, particularly filopodia and lamellipodies in developing Rat CNS and embryonic neurons in culture.
Studies suggest that 2G13P interacts with the filamentous actin cytoskeleton and therefore may be involved in Growth Cone motility (Stettler et al. 1999).
Mouse anti Growth Cone antibody, Clone 2G13 has been used for the detection of growth cones by immunohistochemistry and identification of 40S ribosomal protein SA by Western blotting in Chicken and Rat samples (Baloui et al. 2004).
Chicken, Rat and Mouse.
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