TA328720 BAI1 antibody

Rabbit Polyclonal Anti-BAI1 (extracellular)

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Search for all "BAI1"

0.2 ml / €622.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat BAI1

TA328720

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Product Description for BAI1

Rabbit anti Human, Mouse, Rat BAI1.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for BAI1

Product Category Primary Antibodies
Target Category
Quantity 0.2 ml
Synonyms BAI-1, Brain-specific angiogenesis inhibitor 1
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q3UHD1
Immunogen:
Peptide (C)GRVRTYQFDSFLESTR, corresponding to amino acid residues 97-112 of mouse BAI1. Extracellular, N-terminus.
GeneID:
107831
Application WB: 1:200-1:2000; IHC: 1:100-1:3
000; FC: 1:50-1:600;
Background The three members of the brain angiogenesis inhibitor (BaI1-3) are receptors belonging to the adhesion subfamily of G-protein coupled receptor superfamily. Like all members of GPCRs, all three BaIs have seven transmembrane domains, an intracellular C-termil tail and extracellular N-terminus. Like other adhesion members, the N-terminus is quite large. Many domains are localized to the N-terminus; various glycosylations sites are present, there is a GPCR proteolysis site, a putative hormone binding domain and thrombospondin type 1 repeats which regulate the anti-angiogenic activity of thrombospondin-1. The C-termil tail interacts with PDZ-domain proteins. Unique to BaI1 is a proline-rich domain required for interacting with Src homology domains and WW domain proteins. Like most adhesion GPCRs, BaI also undergo proteolysis at the N-terminus at a highly rich cystein domain. Following autocleavage, the N-termil fragment remains associated to the receptor. In BaI1, proteolysis yields a partly secreted 120 kDa. fragment (vasculostatin-120) or a 40 kDa. fragment both having antiangiogenic effects. At the mR level, all BaIs are expressed in fetal and adult human brain. BaI2 is detected in the human heart and skeletal muscle. BaI3 is expressed in the human heart, testis and small intestine. In mouse, both BaI2 and BaI3 are restricted to the brain. These receptors are implicated in various diseases and disorders such as primary glioma, pulmory adenocarcinomas, gastric and colorectal cancers.
Format
Purification:
Affinity purified on immobilized antigen.
Buffer System:
Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
State:
Purified

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