discontinued

NBP1-28566 Bax antibody

See related secondary antibodies

Search for all "Bax"

Quick Overview

Mouse anti Human, Mouse, Rat Bax 6A7

NBP1-28566

Product Description for Bax

Mouse anti Human, Mouse, Rat Bax 6A7.
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot.

Properties for Bax

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-Apoptosis regulator BAX cytoplasmic isoform b, anti-Apoptosis regulator BAX membrane isoform alph, anti-BAX protein cytoplasmic isoform delta antibod, anti-BCL2 associated X protein antibody, anti-Bax isoform psi antibody, anti-Bax protein cytoplasmic isoform delta. antibo, anti-Bax protein cytoplasmic isoform gamma antibod, anti-Bax zeta antibody, anti-apoptosis regulator BAX antibody
Presentation Purified
Reactivity Hu, Ms, Rt
Applications C, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone 6A7
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
KLH-conjugated peptide corresponding to amino acids 12-24 located near the Nterminus common to human, mouse and rat Bax (1)
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Application ELISA, immunofluorescence, immunoprecipitation, Western Blot, ELISA, Immunofluorescence, Immunoprecipitation and Western Blot, ELISA , immunofluorescence , immunoprecipitation , Western Blot ≤ 1 ug/ml
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (2) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (3) Bax is a member of the Bcl-2 family of apoptosis-associated proteins and, although it is similar in structure to Bcl-2, Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and subsequent cell death in a caspase-independent manner, presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer, Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program. (4-13) The monoclonal antibody 2D2 is specific for human Bax. (1)
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Human, mouse and rat Bax (Mr 20-22 kDa)
Species:
Human, Mouse, Rat

Accessory Products

  • LinkedIn