NBP1-28566 Bax antibody

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0.1 mg / €380.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human, Mouse, Rat Bax 6A7

NBP1-28566

Product Description for Bax

Mouse anti Human, Mouse, Rat Bax 6A7.
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot.

Properties for Bax

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-Apoptosis regulator BAX cytoplasmic isoform b, anti-Apoptosis regulator BAX membrane isoform alph, anti-BAX protein cytoplasmic isoform delta antibod, anti-BCL2 associated X protein antibody, anti-Bax isoform psi antibody, anti-Bax protein cytoplasmic isoform delta. antibo, anti-Bax protein cytoplasmic isoform gamma antibod, anti-Bax zeta antibody, anti-apoptosis regulator BAX antibody
Presentation Purified
Reactivity Hu, Ms, Rt
Applications C, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone 6A7
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
KLH-conjugated peptide corresponding to amino acids 12-24 located near the Nterminus common to human, mouse and rat Bax (1)
Isotype control SM20P (for use in rat samples)
Application ELISA, immunofluorescence, immunoprecipitation, Western Blot, ELISA, Immunofluorescence, Immunoprecipitation and Western Blot, ELISA , immunofluorescence , immunoprecipitation , Western Blot ≤ 1 ug/ml
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (2) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (3) Bax is a member of the Bcl-2 family of apoptosis-associated proteins and, although it is similar in structure to Bcl-2, Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and subsequent cell death in a caspase-independent manner, presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer, Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program. (4-13) The monoclonal antibody 2D2 is specific for human Bax. (1)
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Human, mouse and rat Bax (Mr 20-22 kDa)
Species:
Human, Mouse, Rat

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