TA306174 Bcl-2-like 8 antibody

Rabbit Polyclonal BAD Antibody

See related secondary antibodies

Search for all "Bcl-2-like 8"

0.1 mg / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat Bcl-2-like 8

TA306174

More Views

  • TA306174
  • TA306174

Product Description for Bcl-2-like 8

Rabbit anti Human, Mouse, Rat Bcl-2-like 8.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for Bcl-2-like 8

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms BAD, BBC6, BCL2L8, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl-XL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bcl2-L-8
Presentation Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q92934
Immunogen:
Murine Bad / Bcl-2-like 8 Peptide (AP30114CP-N)
GeneID:
572
Add. information Blocking peptide available: blocking peptide (AP30114CP-N)
Application ELISA.
Western Blot: Bad antibody can be used for detection of Bad at 0.5 to 1 μg/ml.
Immunohistochemistry.
Background Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death (reviewed in 1 and 2). Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax (3). Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival (4), whereas JNK-induced phosphorylation promotes the apoptotic role of Bad (5).
General Readings
  1. Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003 Nov 24;22(53):8590-607. PubMed PMID: 14634621.
  2. Heiser D, Labi V, Erlacher M, Villunger A. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp Gerontol. 2004 Aug;39(8):1125-35. PubMed PMID: 15288687.
  3. Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, et al. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J Biol Chem. 1997 Dec 5;272(49):30866-72. PubMed PMID: 9388232.
  4. Zhou XM, Liu Y, Payne G, Lutz RJ, Chittenden T. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem. 2000 Aug 11;275(32):25046-51. PubMed PMID: 10837473.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Ion exchange chromatography
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
Bad antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad.
Species:
Human, Mouse, Rat.

Accessory Products

Proteins and/or Positive Controls

Proteins for Bcl-2-like 8 (15 products)

Catalog No. Species Pres. Purity   Source  

Bcl-2-like 8 (transcript variant 1)

Bcl-2-like 8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Bcl-2-like 8 (full length, N-term HIS tag, transcript variant 2)

Bcl-2-like 8 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Bcl-2-like 8

Bcl-2-like 8 Human Purified E. coli
  Acris Antibodies GmbH

Bcl-2-like 8

Bcl-2-like 8 Human Purified E. coli
  Acris Antibodies GmbH

Bcl-2-like 8

Bcl-2-like 8 Human Purified E. coli
  Acris Antibodies GmbH

Bcl-2-like 8

Bcl-2-like 8 Human
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human
  Abnova Taiwan Corp.

Bcl-2-like 8

Bcl-2-like 8 Human
  Abnova Taiwan Corp.

Positive controls for Bcl-2-like 8 (1 products)

Catalog No. Species Pres. Purity   Source  

Bad Lysate

Western Blot: Bad Lysate [NBL1-07900] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for BAD. Protein
  Novus Biologicals Inc.
  • LinkedIn