NBP1-22776 Bcl10 (151) antibody

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0.5 ml / €360.00

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Mouse anti Human Bcl10 (151) 151


Product Description for Bcl10 (151)

Mouse anti Human Bcl10 (151) 151.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Bcl10 (151)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-B cell CLL/lymphoma 10 antibody, anti-B cell lymphoma/leukemia10 antibody, anti-Bcl 10 antibody, anti-CARD containing apoptotic signaling protein a, anti-CARD containing molecule enhancing NF kB anti, anti-CARD containing molecule enhancing NF kappa B, anti-CARD containing molecule enhancing NFkB antib, anti-CARD containing proapoptotic protein antibody, anti-CARD like apoptotic protein antibody, anti-CARMEN antibody, anti-CED 3/ICH 1 prodomain homologous E10 like reg, anti-CED3/ICH1 prodomain homologous E10 like regul, anti-CIPER antibody, anti-CLAP antibody, anti-Caspase recruiting domain containing protein, anti-Cellular E10 antibody, anti-Cellular homolog of vCARMEN antibody, anti-Mammalian CARD containing adapter molecule E1, anti-c E10 antibody, anti-cCARMEN antibody, anti-cE 10 antibody, anti-cE10 antibody, anti-hCLAP antibody, anti-mE 10 antibody, anti-mE10 antibody
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone 151
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Human recombinant Bcl-10
Isotype control AM03095PU-N
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:100
Background Bcl10 / CIPER/ CLAP / mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase9 to induce apoptosis. It is a cellular homolog of equine herpes virus 2 E-10. It is known to induce activation of JNK, p38 and NF kappaB. Mutations in Bcl10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.
Storage Store at 4C. Do not freeze.
protein G purified
Buffer System:
Sodium Azide
protein G purified
Monoclonal Anti-Bcl-10 reacts specifically with human Bcl-10. The epitope recognized by the resides within amino acids 122-168 of human Bcl-10 molecule. Bcl-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protien. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF-kB activation. Deregulation of Bcl-10 expression is also demonstrated to be involved in cellular oncogenesis.

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