NBP1-22524 Bcl2 (124) antibody

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Mouse anti Human Bcl2 (124) 124


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  • NBP1-22524

Product Description for Bcl2 (124)

Mouse anti Human Bcl2 (124) 124.
Presentation: Supernatant
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Bcl2 (124)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-Apoptosis regulator Bcl 2 antibody, anti-Apoptosis regulator Bcl2 antibody, anti-B cell CLL/lymphoma 2 antibody, anti-B cell leukemia/lymphoma 2 antibody, anti-B cell lymphoma 2 antibody, anti-BCL2 protein antibody, anti-Bcl 2 antibody, anti-Bcl2 antibody
Presentation Supernatant
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone 124
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant bcl-2 peptide sequence comprising of 51-54 amino acids of bcl-2 oncoprotein.
Application immunohistochemistry, Western Blot, Western Blot and ABC, Western Blot 1:100-750, immunohistochemistry 1:15-1:50
Background BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants (alpha and beta) produced by alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF1). It can form homodimers, and heterodimers with BAX, BAD, BAK and BclX(L). Heterodimerization with BAX requires intact BH1 and BH2 domains, and is necessary for anti-apoptotic activity. Also interacts with APAF1, RAF1, TP53BP2, BBC3, BCL2L1 and BNIPL. Bcl-2 is encoded by a gene involved in the 14; 18 chromosomal translocation. In lymphoid tissues, this antibody stains B lymphocytes as well as T cells.
Storage Store at 4C. Do not freeze.
Tissue culture supernatant
Buffer System:
Sodium Azide
Tissue culture supernatant
This is specific to bcl-2 oncoprotein, encoded by a gene involved in the 14; 18 chromosomal translocation. In lymphoid tissues, this stains B- lymphocytes as well as T cells.

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