discontinued

NBP1-28563 BCL2L1 (2H12) antibody

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0.1 mg / €370.00

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Mouse anti Human BCL2L1 (2H12) 2H12

NBP1-28563

Product Description for BCL2L1 (2H12)

Mouse anti Human BCL2L1 (2H12) 2H12.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for BCL2L1 (2H12)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-Apoptosis regulator Bcl X antibody, anti-BCL XL/S antibody, anti-BCL2L antibody, anti-BCLX antibody, anti-Bcl 2 like 1 antibody, anti-Bcl 2 like 1 protein antibody, anti-Bcl xL antibody, anti-Bcl xS antibody, anti-Bcl2 like1 antibody, anti-Bcl2l1 antibody, anti-DKFZp781P2092 antibody
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone 2H12
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
KLH-conjugated peptide corresponding to amino acids 3-14 near the N-terminus mouse and human Bcl-xL (1)
Isotype control AM03096PU-N
Add. information Research Areas: Cancer
Application immunohistochemistry, Western Blot, Western Blot and Immunohistochemistry, immunohistochemistry 5-10 ug/mL, Western Blot ≤ 1 ug/ml
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (1) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (2) Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis (3,4), while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. (5-8) Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. (9-13) In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, (5,14) other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity. (15,16) Mab 7B2.5 recognizes both human and rodent Bcl-xL. (17)
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Mouse and human Bcl-xL (Mr 29 kDa)
Species:
Human

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