discontinued

NBP1-28562 BCL2L1 (7B2.5) antibody

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50 µg / €370.00

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Mouse anti Human BCL2L1 (7B2.5) 7B2.5

Product Description for BCL2L1 (7B2.5)

Mouse anti Human BCL2L1 (7B2.5) 7B2.5.
Presentation: PE
Product is tested for Frozen Sections, Flow Cytometry, Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot.

Properties for BCL2L1 (7B2.5)

Product Category Primary Antibodies
Quantity 50 µg
Synonyms anti-Apoptosis regulator Bcl X antibody, anti-Apoptosis regulator BclX antibody, anti-B cell lymphoma 2 like antibody, anti-BCL XL/S antibody, anti-BCL2L antibody, anti-BCLX antibody, anti-Bcl 2 like 1 protein antibody, anti-Bcl X antibody, anti-Bcl xL antibody, anti-Bcl xS antibody, anti-Bcl2 Like 1 antibody, anti-Bcl2 related gene antibody, anti-Bcl2l1 antibody, anti-BclXL antibody, anti-BclXs antibody, anti-DKFZp781P2092 antibody
Presentation PE
Reactivity Hu
Applications C, F, IP, P, WB
Clonality Monoclonal
Clone 7B2.5
Host Mouse
Isotype IgG3
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant Bcl-xS
Isotype control AM08210RP-N
Add. information Protect conjugated forms from light.
Application flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot, Flow cytometry / FACS analysis, Immunoprecipitation, Western Blot and Immunohistochemistry, flow cytometry / FACS analysis ≤ 3 ug/1^6 cells, immunohistochemistry , immunoprecipitation , Western Blot
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (1) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (2) Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis (3,4), while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. (5-8) Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. (9-13) In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, (5,14) other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity. (15,16) Mab 7B2.5 recognizes both human and rodent Bcl-xL. (17)
Storage Store at 4C. Do not freeze.
Format
Label:
R-Phycoerythrin
PE
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
Specificity
Specificity:
Human Bcl-xL (Mr 29 kDa)
Species:
Human

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