NB910-95610 Beclin 1 Pack antibody

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anti Human, Mouse, Rat Beclin 1 Pack


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  • NB910-95610
  • NB910-95610
  • NB910-95610
  • NB910-95610
  • NB910-95610

Product Description for Beclin 1 Pack

anti Human, Mouse, Rat Beclin 1 Pack.
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Beclin 1 Pack

Product Category Primary Antibodies
Quantity 3 vials
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

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Add. information 1 vial each of: NB500-249, NB500-266 and NB110-87318.
Research Areas: Cancer
Application Immunohistochemistry-Paraffin, Western Blot, Mainly western blot and immunohistochemistry on paraffin sections. However, additional applications may be possible for individual products.
Background Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Human, Mouse, Rat

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