AM26348PU-N Benzo(a)pyrenediol-epoxide (BPDE) antibody

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0.1 mg / €450.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Benzo(a)pyrenediol-epoxide (BPDE) 8E11

AM26348PU-N

Product Description for Benzo(a)pyrenediol-epoxide (BPDE)

Mouse anti Benzo(a)pyrenediol-epoxide (BPDE) 8E11.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Benzo(a)pyrenediol-epoxide (BPDE)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms PAH, polycyclic aromatic hydrocarbon
Presentation Purified
Applications E
Clonality Monoclonal
Clone 8E11
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Immunoassays (detector).
Useful for Immunopurification.
Background A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.
Concentration 0.1 mg/ml
General Readings
  1. Santella RM, Gammon MD, Zhang YJ, Motykiewicz G, Young TL, Hayes SC, et al. Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue. Cancer Lett. 2000 Jun 30;154(2):143-9. PubMed PMID: 10806302.
  2. Mumford JL, Williams K, Wilcosky TC, Everson RB, Young TL, Santella RM. A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues. Mutat Res. 1996 Apr 4;359(3):171-7. PubMed PMID: 8618549.
  3. Santella, R et al; Monoclonal antibodies to DNA modified by benzo[a]pyrene diol epoxide. Carcinogenesis 1984, 5: 373. 
Storage

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Format
Purification:
Protein G
Buffer System:
PBS
Preservatives:
0.02% sodium azide
Stabilizers:
0.1% bovine serum albumin
State:
Liquid 0.2 µm filtered Ig fraction
Purified
Specificity
Specificity:
The monoclonal antibody 8E11 recognizes free BPDE and DNA adducts.

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