TA306601 BICD1 antibody

Rabbit Polyclonal BICD1 Antibody

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0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat BICD1

TA306601

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  • TA306601
  • TA306601

Product Description for BICD1

Rabbit anti Human, Mouse, Rat BICD1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for BICD1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Bic-D1, Protein bicaudal D homolog 1
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q96G01
Immunogen:
BICD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BICD1. (AP30144CP-N)
GeneID:
636
Add. information Blocking peptide available: blocking peptide (AP30144CP-N)
Application ELISA.
Western Blot: BICD1 antibody can be used for detection of BICD1 at 0.5 – 1 μg/ml.
Immunocytochemistry.
Background BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells. At least two isoforms of BICD1 are known to exist.
General Readings
  1. Baens M, Marynen P. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Genomics. 1997 Nov 1;45(3):601-6. PubMed PMID: 9367685.
  2. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002 Dec;4(12):986-92. PubMed PMID: 12447383.
  3. Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, et al. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. Exp Cell Res. 2007 Oct 1;313(16):3408-20. Epub 2007 Jul 17. PubMed PMID: 17707369.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody reacts to BICD1.
This antibody will only recognize the larger isoform.
Species:
Human, Mouse, Rat.

Accessory Products

Proteins and/or Positive Controls

Proteins for BICD1 (3 products)

Catalog No. Species Pres. Purity   Source  

BICD1 (transcript variant 1)

BICD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

BICD1

BICD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BICD1

BICD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for BICD1 (1 products)

Catalog No. Species Pres. Purity   Source  

BICD1 overexpression lysate

BICD1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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