discontinued

NBP1-28594 Bid (SB50a) antibody

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0.1 mg / €430.00

Quick Overview

Mouse anti Human Bid (SB50a) SB50a

NBP1-28594

Product Description for Bid (SB50a)

Mouse anti Human Bid (SB50a) SB50a.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.

Properties for Bid (SB50a)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-Apoptotic death agonist BID antibody, anti-BH3 interacting domain death agonist Antibody, anti-BH3 interacting domain death agonist p11 anti, anti-BH3 interacting domain death agonist p13 anti, anti-BH3 interacting domain death agonist p15 anti, anti-BID isoform ES(1b) antibody, anti-BID isoform L(2) antibody, anti-Desmocollin type 4 antibody, anti-p11 BID antibody, anti-p13 BID antibody, anti-p15 BID antibody, anti-p22 BID antibody
Presentation Purified
Reactivity Hu
Applications E, IP, WB
Clonality Monoclonal
Clone SB50a
Host Mouse
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Isotype control AM03110PU-N, SM12P
Application ELISA, immunoprecipitation, Western Blot, ELISA, Western Blot and Immunoprecipitation , ELISA , immunoprecipitation , Western Blot
Background Members of the Bcl-2 family are pro- or antiapoptotic proteins that process one or several of the Bcl-2 homology (BH) domains. Bid is a proapoptotic, BH3-domain-only member or BH3-only protein (BOP) of the Bcl-2 family. Bid is localized in the cytosolic fraction of living cells as an inactive precursor. Activation of Bid occurs upon its cleavage by caspase-8 in the Fas and TNF-alpha apoptotic signaling pathways. Recent studies have suggested that Bid is also cleaved and activated by granzyme B, calpain and lysosomal extracts. Cleaved Bid translocates to mitochondria where it induces the release of cytochrome c from the intermembrane space of the mitochondria. The release of cytochrome c initiates apoptosis by activating downstream caspases through binding to Apaf-1. Bid has also been shown to interact with with Bax, another Bcl-2 family protein, to trigger a conformational change in Bax leading to the dimerization and integration of Bax into the outer mitochondrial membrane and activating the release of cytochrome c. (1-10)
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
State:
Purified
Specificity
Species:
Human

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