discontinued

NB100-94263 BIRC8 antibody

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0.1 mg / €400.00

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Rabbit anti Human BIRC8

Product Description for BIRC8

Rabbit anti Human BIRC8.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for BIRC8

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-ILP-2 polyclonal antibody was raised with a synthetic peptide (TGYEARLITFGT) corresponding to amino acids 2 to 13 of human ILP-2 (1).
Application Western Blot, This antibody can be used for detection of ILP-2 by Western blot at 1 to 2 ug/ml. Human HepG2 or MOLT4 cell lysate can be used as a positive control and a band at approximately 33 kDa can be detected. It is human specific., Western Blot 1-2 ug/ml,
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
0.02% Sodium Azide
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
ILP-2
Species:
Human

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