discontinued

NB100-65974 Bleomycin antibody

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Search for all "Bleomycin"

1000 Tests / €410.00

Quick Overview

Sheep anti All Species Bleomycin

NB100-65974

Product Description for Bleomycin

Sheep anti All Species Bleomycin.
Presentation: Serum
Product is tested for Radioimmunoassay.

Properties for Bleomycin

Product Category Primary Antibodies
Quantity 1000 Tests
Presentation Serum
Reactivity All Species
Applications R
Clonality Polyclonal
Host Sheep
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide corresponding to part of the native molecule conjugated to Bovine Serum Albumin.
Application , Radioimmunoassays, Radioimmunoassay
Background Bleomycin is a glycosylated linear nonribosomal peptide antibiotic produced by the bacterium Streptomyces verticillus. It is used in the treatment of Hodgkin lymphoma (as a component of the ABVD regimen), squamous cell carcinomas, and testicular cancer as well as pleurodesis. Bleomycin acts by induction of DNA strand breaks. Some studies suggest that bleomycin also inhibits incorporation of thymidine into DNA strands. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. In addition, these complexes also mediate lipid peroxidation and oxidation of other cellular molecules.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Whole antisera
Buffer System:
No Preservative
Purity:
Whole antisera
State:
Serum
Specificity
Specificity:
Synthetic peptide corresponding to part of the native molecule conjugated to Bovine Serum Albumin.

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