discontinued

NB100-226 BRCA1 / RNF53 pSer1423 antibody

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Rabbit anti Human BRCA1 / RNF53

Product Description for BRCA1 / RNF53

Rabbit anti Human BRCA1 / RNF53.
Properties: pSer1423
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for BRCA1 / RNF53

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Breast cancer type 1 susceptibility protein, RING finger protein 53
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P38398
Immunogen:
Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1423 according to the numbering given in entry NP_009225.1.
GeneID:
672
Property pSer1423
Add. information Research Areas: Cancer, DNA Repair
Application flow cytometry / FACS analysis, Western Blot, This antibody is useful for Western Blot and FACS (see Zaugg et al). *The investigator should determine the optimal dilution for a specific application., flow cytometry / FACS analysis , Western Blot 1:1000-1:10000,
Background BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer.
Concentration 1 mg/ml
General Readings
  1. Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, et al. Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3805-10. Epub 2007 Feb 26. PubMed PMID: 17360434. (Free PMC Article available, 6 images available)
Storage Store at 4C. Do not freeze.
Format
Purification:
Immunogen affinity purified
Buffer System:
0.1% Sodium Azide
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
NB100-226 reacts with BRCA1
Species:
Human, Mouse
Gene ID 672

Accessory Products

Proteins and/or Positive Controls

Proteins for BRCA1 / RNF53 (5 products)

Catalog No. Species Pres. Purity   Source  

BRCA1 / RNF53

BRCA1 / RNF53 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human Purified > 95 % Insect cells
2 µg / €620.00
  Neuromics Antibodies
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