discontinued

NB100-81826 BRCA1 / RNF53 antibody

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Rabbit anti Human, Mouse, Rat BRCA1 / RNF53

NB100-81826

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  • NB100-81826
  • NB100-81826

Product Description for BRCA1 / RNF53

Rabbit anti Human, Mouse, Rat BRCA1 / RNF53.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for BRCA1 / RNF53

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Breast cancer type 1 susceptibility protein, RING finger protein 53
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P38398
Immunogen:
The antiserum was produced against synthesized non-phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).
GeneID:
672
Add. information Research Areas: Cancer
Application immunohistochemistry, Western Blot, Western Blot and Immunohistochemistry, Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:100
Background BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full length natures identified.
Concentration 1 mg/ml
General Readings Kim ST, et al. (2002) Genes Dev; 16(5): 560-570
Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709
Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718
Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46
Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
Immunogen affinity purified
Buffer System:
0.02% Sodium Azide
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
BRCA1 (specific to a.a. 1423) detects endogenous levels of total BRCA1 protein.
Species:
Human
Gene ID 672

Accessory Products

Proteins and/or Positive Controls

Proteins for BRCA1 / RNF53 (5 products)

Catalog No. Species Pres. Purity   Source  

BRCA1 / RNF53

BRCA1 / RNF53 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BRCA1 / RNF53

BRCA1 / RNF53 Human Purified > 95 % Insect cells
2 µg / €620.00
  Neuromics Antibodies
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