GTX17968 BRD8 antibody

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0.1 mg / €440.00

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Rabbit anti Human BRD8


Product Description for BRD8

Rabbit anti Human BRD8.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for BRD8

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic peptide: LCLASS VMRSGDQNWV SVSRAIKPFA EPGRPPDWFSQKHCASQYSE LLETT , corresponding to amino acids 25-75 of Human BRD8.
Application IP, WB
Background BRD8 may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Immunogen affinity purified
Buffer System:
Preservative: 0.1% Sodium Azide. Constituents: Tris citrate/phosphate. pH 7-8
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human.Reactivity with mouse BRD8 is likely owing to identity between this ortholog and human BRD8 at the site to which the epitope maps. Not yet tested in other species.

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